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A new class of regulatory non coding RNAs -
If you're interested in micro RNAs, then it may be time to consider the T-UCRs?
Transcribed Ultra Conserved Regions (T-UCRs) represent a group of 481 highly conserved sequences in vertebrates that are transcribed into RNA. Very little is known about their mechanism of action, but their perfect conservation over millions of years of evolutionary time suggests an important regulatory role in gene expression. T-UCR sequences are non coding so may influence gene expression analogous to micro RNAs or by acting as antisense inhibitors of coding mRNAs.
· T-UCR sequences are 100% conserved between human mouse and rat
· Only 25% of T-UCR sequence over lap with coding regions
· Expression is ubiquitous throughout all tissues
· Tissues have a unique T-UCR signature
· The expression of T-UCR sequences is altered in disease states such as cancer
References
‘Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas’ Cancer Cell 12, 215–229, September 2007 (abstract)
‘Ultraconserved Elements in the Human Genome’ Science VOL 304 p1321 (abstract)
Product features
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Exciting new research target
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Validated primer available for all 481 T-UCR sequences
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Professionally designed
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Optional positive control cDNA available from our Biobank
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Kit contents
Lyophilised primer sets for each T-UCR, PCR grade water.
Sample data (click for details)
T-UCR sample data
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T-UCR assays for free! Below you can click through to the list price for T-UCR primers. However, to encourage scientists to explore this exciting new field of biology, we are giving away T-UCR primers for free if they are ordered alongside Precision MasterMix to run your experiment. Please click for full details.
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T-UCR |
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T-UCR complete. Primers for all 481 sequences |
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T-UCR 120 |
Primers for T-UCR sequences 1-120 |
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T-UCR 240 |
Primers for T-UCR sequences 121-240 |
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T-UCR 360 |
Primers for T-UCR sequences 241-360 |
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T-UCR 481 |
Primers for T-UCR sequences 361-481 |
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If you require a specific combination of T-UCR primer sets then please email us for a quote (email)
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